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Association Between Migraine and Periodontitis: A Systematic Review and Meta-Analysis
Gabriel Bernat Camps-Plomer1, Cecilia Fabiana Márquez-Arrico1, José Enrique Iranzo-Cortés1
1University of Valencia, Medicine and Dentistry Faculty, Stomatology Department, Valencia, Spain.
European Journal of Neurology
|October 22, 2025
Summary
This study found a significant link between periodontitis and migraine. Individuals with periodontitis have an increased risk of experiencing migraine headaches.
Area of Science:
- Neurology
- Periodontology
- Public Health
Background:
- Migraine affects one billion people globally, presenting with stabbing pain and hypersensitivity.
- Periodontitis, a common dental disease, can lead to tooth loss and has systemic implications.
- The potential link between periodontitis and migraine warrants further investigation.
Purpose of the Study:
- To systematically review and synthesize scientific evidence connecting periodontitis and migraine.
- To determine the statistical association between these two conditions.
Main Methods:
- A systematic review and meta-analysis of four major databases (PubMed, Web of Science, Scopus, Embase).
- Inclusion of 8 articles for review and 6 for meta-analysis, utilizing the Random Forest model for data combination.
Main Results:
- A statistically significant odds ratio (OR) of 1.8 (95% CI: 1.4-2.32) was estimated for the association.
- The meta-analysis confirmed a significant OR of 4.55 (p < 0.001), indicating a strong relationship.
- Publication bias was assessed using Egger's regression, revealing a significant intercept (p=0.007).
Conclusions:
- The meta-analysis demonstrates a statistically significant relationship between periodontitis and migraine.
- Identified risk factors like smoking, stress, and comorbidities such as obesity and diabetes may influence this association.
