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Updated: Jan 14, 2026

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
Challenges and opportunities in nanotherapeutics targeted for central nervous system disorders
Joel Yong1, Karen Hakobyan1, Sk Al Zaheri Mahmud1
1School of Chemical Engineering, University of New South Wales, Sydney 2052, Australia. guangzhao.mao@ed.ac.uk.
Abstract:
Central nervous system (CNS) disorders represent some of the most challenging problems for modern medicine. The complexity of the CNS structure, incomplete understanding of disease, chronic neuroinflammation, and physiological barriers limiting drug delivery all contribute to the difficulty of treating neurological diseases. This review covers the neuroanatomical barriers of the CNS and discusses current treatments, shortcomings of these treatments, recent clinical trials, and opportunities for nanotherapeutic approaches in common CNS disorders. Focus is placed on selected CNS disorders stemming from trauma, neurodegenerative diseases and infectious diseases. The review concludes with a summary and perspectives on the nanotherapeutics development highlighting key challenges and future directions for the field.
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