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Related Concept Videos

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
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Cellular Reprogramming and Microfluidics Enable Large-Scale Blastoid Production from Aged Donors.

Marcelo Tigre Moura1

  • 1Departamento de Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal da Paraíba (UFPB), João Pessoa, Brasil.

Cellular Reprogramming
|October 22, 2025
PubMed
Summary

Researchers developed a new method to create blastoids, or early embryo models, from rhesus monkeys. This breakthrough advances developmental biology research using nonhuman primate blastoids.

Area of Science:

  • Developmental Biology
  • Stem Cell Research
  • Primate Models

Background:

  • Blastoids, stem cell models mimicking preimplantation embryos, are crucial for studying early development and diseases.
Keywords:
Macaca mulattaembryo modelsinduced pluripotencymicrofluidicsnuclear transplantation

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  • Existing blastoid technology is advanced in mice and humans, but limited in nonhuman primates.