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Related Experiment Video

Updated: Jan 14, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
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Intricate interplay between fungi and neutrophils.

Yi-Fen Cheng1, Hsin-Yu Liao1, Tzu-Yu Hsieh1

  • 1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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|October 22, 2025
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Summary

Environmental cues, like fungi, shape neutrophil development, making them more human-like. This research explores fungal-neutrophil interactions and their therapeutic potential for immune disorders.

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Area of Science:

  • Immunology
  • Microbiology
  • Cell Biology

Background:

  • Neutrophils are key immune cells with distinct human and mouse characteristics.
  • Environmental factors, particularly fungal exposure, influence neutrophil development and function.
  • Intestinal fungi play a role in granulopoiesis and immune activation beyond infection.

Purpose of the Study:

  • To review the complex interactions between fungi and neutrophils.
  • To examine how fungal components affect neutrophil activation, differentiation, and immune function.
  • To discuss the impact of gut mycobiota on disease and potential therapeutic strategies.

Main Methods:

  • Literature review of studies on fungal-neutrophil interactions.
  • Analysis of research on environmental influences on neutrophil ontogeny.
  • Exploration of mechanisms underlying fungal colonization and infection responses.

Main Results:

  • Fungal exposure can modify neutrophil development towards human-like characteristics.
  • Fungal components directly influence neutrophil activation and differentiation.
  • Gut mycobiota impacts disease progression and immune responses.

Conclusions:

  • Fungal-neutrophil interactions are critical in immune regulation.
  • Targeting these interactions offers potential therapeutic avenues for immune-related disorders.
  • Understanding neutrophil ontogeny in response to environmental cues is crucial for immune health.