Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

777
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
777
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

437
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
437
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

627
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
627
Long-term Depression01:03

Long-term Depression

3.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.1K
Long-term Depression01:05

Long-term Depression

33.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards disentangling the polygenic contribution of dyslexia to school performance.

Translational psychiatry·2026
Same author

Psychosis Related to Nitrous Oxide Misuse: A Case Series and Systematic Review.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2026
Same author

Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort: Results From the DISCOvERIE Project.

United European gastroenterology journal·2025
Same author

Remote monitoring of wide-ranging real-world changes in adults following ADHD medication initiation.

Translational psychiatry·2025
Same author

Author Correction: Fine-mapping genomic loci refines bipolar disorder risk genes.

Nature neuroscience·2025
Same author

Comparative Bioavailability of Methylphenidate Powder for Prolonged-Release Oral Suspension and Methylphenidate Prolonged-Release Chewable Tablets versus Methylphenidate Immediate-Release Tablets: Phase 1, Single-Dose, Randomised, Crossover Studies in Healthy Adults.

Clinical drug investigation·2025

Related Experiment Video

Updated: Jan 14, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

29.4K

Performance of Automatic Speech Analysis in Detecting Depression: Systematic Review and Meta-Analysis.

Patricia Laura Maran1,2, María Dolores Braquehais1,3,4,5, Alexandra Vlaic6

  • 1Psychiatry, Mental Health and Addictions Group, Vall d'Hebron Research Institute (VHIR), Instituto de Investigación Sanitaria Acreditado Instituto de Investigación - Hospital Universitario Vall d'Hebron (IR-HUVH), Barcelona, Catalonia, Spain.

JMIR Mental Health
|October 22, 2025
PubMed
Summary

Automatic speech analysis (ASA) shows promise for depression detection, with pooled accuracy around 81%. However, it is currently best used as a complementary tool, not a standalone diagnostic method.

Keywords:
AIartificial intelligenceautomatic speech analysisdepressionmeta-analysismobile phone

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.2K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.2K

Related Experiment Videos

Last Updated: Jan 14, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

29.4K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.2K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.2K

Area of Science:

  • Mental Health
  • Artificial Intelligence
  • Speech Analysis

Background:

  • Depression is prevalent and often underdiagnosed.
  • Automatic speech analysis (ASA) offers a potential solution for depression assessment.
  • A comprehensive evaluation of ASA's diagnostic accuracy is needed.

Purpose of the Study:

  • To systematically review and meta-analyze the diagnostic performance of ASA for depression detection.
  • To evaluate both machine learning and deep learning approaches in ASA for depression assessment.

Main Methods:

  • Systematic search of 8 databases (Jan 2013-Apr 2025) for English-language studies on ASA for depression.
  • Inclusion of studies reporting diagnostic accuracy metrics.
  • Quality assessment using a modified QUADAS-R.
  • 3-level meta-analysis to estimate pooled accuracy, sensitivity, specificity, and precision.
  • Meta-regression and subgroup analyses to explore heterogeneity.

Main Results:

  • 105 studies met inclusion criteria from 1345 records.
  • Pooled highest accuracy: 0.81 (95% CI 0.79-0.83).
  • Pooled highest sensitivity: 0.84 (95% CI 0.81-0.86).
  • Pooled highest specificity: 0.83 (95% CI 0.79-0.86).
  • Pooled highest precision: 0.81 (95% CI 0.77-0.84).
  • Pooled lowest accuracy: 0.66 (95% CI 0.63-0.69).

Conclusions:

  • ASA demonstrates potential for depression detection.
  • Clinical application as a standalone tool is currently limited.
  • ASA is best utilized as a complementary method across various settings.
  • Further high-quality research is required for robust and generalizable models.