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An Overview of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Models: Applications to
Deni Hardiansyah1, Bisma Barron Patrianesha2, Kuangyu Shi3
1Medical Physics and Biophysics Research Group, Department of Physics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Indonesia.
Abstract:
This review discusses the current applications, advantages, and limitations of physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical kinetics by integrating prior physiologic and drug parameter information, whereas PopPK models leverage population data to enhance individual dose estimation accuracy. Future directions include developing hybrid models, incorporating artificial intelligence, and establishing regulatory guidelines to promote their clinical adoption. Ultimately, these modeling strategies aim to enable precise, personalized RPT dosing, thereby improving therapeutic outcomes and safety.
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