Related Experiment Video
Updated: Jun 25, 2026

Piezo High Accuracy Surgical Osteal Removal PHASOR: A Technique for Improved Cranial Window Surgery in Mice
Published on: March 2, 2018
Piezoelectric-Driven Cu2+/Cu+ Conversion Strategy for Amplifying Cuproptosis and Oxidative Stress
Xujian Yang1,2, Gao He3, Jiarui Wang1,2
1School of Rare Earths, University of Science and Technology of China, Hefei 230026, China.
Abstract:
To overcome the efficiency limitations of cuproptosis in oncology, we engineered a piezoelectric Cu-loaded Bi4Ti3O12 nanosheet system for synergistic cuproptosis and ROS-mediated tumor therapy. The incorporation of Cu2+ not only enhanced the material's piezoelectric coefficient (d33 = 22.3 pm·V-1) but also facilitated valence-state modulation under ultrasound (US) stimulation. The resulting piezoelectric field significantly promoted charge separation, accelerating Cu2+/Cu+ conversion and boosting reactive oxygen species (ROS) generation. This strategy synergistically induces tumor cell death through a dual tumoricidal pathway: on one hand, the accumulation of Cu+ under US stimulation further amplifies cuproptosis, and on the other hand, the continuous accumulation of ROS triggers excessive oxidative stress. In a murine breast cancer model, this synergistic approach achieved a 90.6% tumor inhibition rate. This study pioneeringly combines piezoelectric material properties and copper valence transformation, providing insights for breast cancer treatment.
Related Concept Videos
Voltaic/Galvanic Cells
Spontaneous redox reactions occur abundantly in nature. The chemical reaction occurring in a disposable AA battery powering our remote controls is one such example of a spontaneous redox reaction. Another example is the immersion of coiled copper wire into an aqueous silver nitrate solution. The reaction shows a gradual, visually impressive color change from colorless to bright blue and the formation of a grey precipitate on the copper wire. In this experiment,...
Controlled-Potential Coulometry: Electrolytic Methods
The chosen potential ensures...
Electrodeposition
Electrodeposition can...
Electrochemical Systems
Electrochemical Cells
Types of Reversible Electrodes

