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Vaccine Coverage Among People With Cystic Fibrosis: A National Multicenter Cross-Sectional Study in Israel
Lior Tsviban1, Nofar Amitai1,2, Hagit Levine1,2
1Pulmonary Institute and Graub CF Center, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Vaccination coverage is low in people with cystic fibrosis (pwCF) after their first year of life, especially for routine and booster vaccines. Increased awareness and proactive strategies are crucial for improving immunization rates in this population.
Area of Science:
- Immunology
- Pediatrics
- Public Health
Background:
- Vaccines are critical for public health, but coverage varies.
- People with cystic fibrosis (pwCF) often exhibit lower vaccination rates than the general population.
Purpose of the Study:
- To assess and compare vaccination coverage in children and adolescents with cystic fibrosis (pwCF) against the general population in Israel.
- To identify specific vaccines with suboptimal coverage in pwCF.
Main Methods:
- A retrospective, multicenter study in Israel.
- Included pwCF born after January 1, 2000.
- Compared vaccination data of 173 pwCF with Ministry of Health reports for the general population.
Main Results:
- Initial DTaP-IPV-HiB vaccine coverage was similar (92% vs. 96%).
- Coverage for other early-life vaccines (HAV, HBV, MMRV) and booster doses was significantly lower in pwCF.
- Influenza vaccination rates were higher in pwCF (65-70%), but COVID-19 vaccine uptake was lower in adolescents (38.5% vs. 57.4%).
Conclusions:
- Vaccine coverage is suboptimal in pwCF, particularly after infancy.
- Routine early-life vaccines and booster doses require more attention.
- Proactive measures are essential to improve immunization rates in pwCF.
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