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Exploring the molecular intersection for hypertension, hyperlipidemia and their comorbid conditions through

Wenjun Li1, Dan Zhou2, Yanmei Ji1

  • 1Department of Cardiovascular Surgery ICU, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Frontiers in Cardiovascular Medicine
|October 23, 2025
PubMed

Insights

This study integrated multi-omics data to map molecular signatures of hypertension and hyperlipidemia. Key metabolites and microbial changes were identified as potential biomarkers for these cardiovascular conditions.

Area of Science:

  • Cardiovascular Research
  • Metabolomics
  • Metagenomics
  • Multi-omics

Background:

  • Hypertension and hyperlipidemia significantly increase cardiovascular risk.
  • The molecular mechanisms underlying these interconnected conditions require further elucidation.
  • Integrated multi-omics approaches are needed to map complex disease signatures.

Purpose of the Study:

  • To conduct an integrated multi-omics investigation of hypertension and hyperlipidemia.
  • To unravel key molecular pathways and biomarkers associated with these conditions.
  • To identify potential diagnostic markers for comorbid hypertension and hyperlipidemia.

Main Methods:

  • Serum metabolomic and fecal metagenomic analyses were performed.
  • Samples were collected from individuals with hypertension, hyperlipidemia, both, and healthy controls.
  • Statistical and pathway analyses were employed to identify significant alterations.

Main Results:

  • Metabolomics revealed altered sphingolipids, phosphatidylcholines, and nucleic acid metabolites.
  • Metagenomics indicated depletion of Fibrobacteres and altered abundances of specific bacteria.
  • Sphingomyelin variants were identified as key diagnostic biomarkers; pathway analysis highlighted alterations in sphingolipid and amino acid metabolism.

Conclusions:

  • The study provides a comprehensive multi-omics landscape of comorbid hypertension and hyperlipidemia.
  • Identified pathways and biomarkers offer potential for precision diagnosis and treatment.
  • This research lays the groundwork for targeted cardiovascular disease management.
Abstract

Keywords:
biomarkerscomorbiditiesmetabolomicsmetagenomicsmicrobiomemulti-omicssphingolipids

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