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Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
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The role of 1,4-palladium migration in C(sp3)-H functionalization

Mohammad Sadegh Karimtabar1, Yasin Mohammadkhani Kalooei1, Fatemeh Doraghi2

  • 1School of Chemistry, College of Science, University of Tehran Tehran Iran.

RSC Advances
|October 23, 2025
PubMed
Summary

This review highlights 1,4-palladium migration as a key strategy for C(sp3)-H functionalization. This method enables selective activation of specific C-H bonds, advancing organic synthesis for pharmaceuticals and natural products.

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