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Related Experiment Video

Updated: May 13, 2026

Low-stress Route Learning Using the Lashley III Maze in Mice
09:14

Low-stress Route Learning Using the Lashley III Maze in Mice

Published on: May 23, 2010

Protocol to test path integration in mice using an L-maze behavioral assay.

Sara I Graves1, Darren J Baker2

  • 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 1(st) ST SW, Rochester, MN 55905, USA.

STAR Protocols
|October 23, 2025
PubMed
Summary

This study introduces a new L-maze protocol to assess path integration (PI) in mice. This method can help detect early neurodegenerative disease by evaluating spatial navigation abilities.

Keywords:
BehaviorModel OrganismsNeuroscience

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Last Updated: May 13, 2026

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Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction
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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Cognitive Science

Background:

  • Path integration (PI) is crucial for navigation, using self-motion cues to determine position.
  • Deficits in PI are linked to cognitive decline and Alzheimer's disease in humans.

Purpose of the Study:

  • To present a novel, dry-land L-maze protocol for assessing path integration in mice.
  • To provide a tool for early detection of neurodegeneration in mouse models.

Main Methods:

  • A three-phase protocol: habituation, training, and testing.
  • Utilizes a dry-land L-maze behavioral assay.
  • Focuses on self-motion cues for spatial estimation.

Main Results:

  • The protocol effectively measures path integration capabilities in mice.
  • It offers a standardized method for behavioral neuroscience research.

Conclusions:

  • This L-maze protocol is a valuable tool for studying path integration in mice.
  • It has potential applications in preclinical research for neurodegenerative diseases like Alzheimer's.