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Radiopharmaceutical Therapy: Rapid Growth, Rising Challenges, and the Critical Need for Expertise.

Heather A Jacene1, Jean-Luc Urbain2, Jason S Lewis3

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Summary

Radiopharmaceutical therapy (RPT) is expanding, requiring nuclear medicine professionals to ensure safe and high-quality patient care. The Society of Nuclear Medicine and Molecular Imaging (SNMMI) provides training and standards for this growing field.

Keywords:
nuclear medicine therapyradiopharmaceuticalstheranostics

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Area of Science:

  • Nuclear Medicine and Molecular Imaging
  • Theranostics
  • Radiopharmaceutical Therapy (RPT)

Background:

  • Theranostics, originating over 80 years ago with radioactive iodine for thyroid disease, has seen recent approvals for neuroendocrine tumors and prostate cancer.
  • Radiopharmaceutical therapy (RPT) is poised for significant expansion across various tumor types.
  • The increasing demand for RPT necessitates a substantial increase in treatment centers and specialized experts.

Purpose of the Study:

  • To emphasize the pivotal role of nuclear medicine and its professionals in delivering high-quality, safe radiopharmaceutical therapy (RPT).
  • To outline the essential components for expanding RPT access, including training, education, regulatory guidance, and collaborations.
  • To highlight the risks associated with administering RPT without adequate training and experience.

Main Methods:

  • The Society of Nuclear Medicine and Molecular Imaging (SNMMI) leverages its established standards and clinical guidelines, continually updated for nuclear medicine and RPT.
  • SNMMI has implemented RPT Centers of Excellence and an accreditation program in collaboration with the International Accreditation Commission (IAC).
  • SNMMI utilizes its Clinical Trials Network (CTN) and Therapy Clinical Trials Network (TCTN) to support research and quality assurance for RPT clinical trials.

Main Results:

  • The expansion of RPT is projected to involve hundreds of thousands of treatment cycles, requiring significant growth in infrastructure and expertise.
  • All nuclear medicine team members undergo accredited training programs focused on safe and effective theranostic radiopharmaceutical selection and use.
  • SNMMI's initiatives aim to ensure consistent quality and safety in RPT delivery through accreditation and research support.

Conclusions:

  • Nuclear medicine professionals are crucial for the safe and effective delivery of radiopharmaceutical therapy (RPT).
  • Standardized training, accreditation, and collaborative efforts are essential to meet the growing demand for RPT.
  • Continued development of best practices and knowledge sharing globally will advance the field of theranostics and RPT.