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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Rapid 3D whole-brain high-resolution T1 quantification: Accelerating standard inversion recovery with

Zhen Hu1,2, Dan Zhu2,3, Yuguo Li2,3

  • 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Magnetic Resonance in Medicine
|October 24, 2025
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Summary

This study introduces a fast inversion recovery (IR) T1 mapping technique using 3D stack-of-spirals turbo FLASH (SOS-TFL) for whole-brain imaging. The method achieves high resolution in minutes, offering accurate T1 quantification without complex acceleration strategies.

Keywords:
T1 mappingcompressed sensinginversion recoverylongitudinal relaxationstack‐of‐spirals turbo FLASH

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Quantitative Imaging
  • Biomedical Engineering

Background:

  • High-resolution T1 quantification is crucial for various MRI applications.
  • Existing methods for whole-brain T1 mapping can be time-consuming.
  • Developing rapid and efficient T1 mapping techniques is a significant challenge.

Purpose of the Study:

  • To propose and evaluate an inversion recovery (IR) based T1 mapping technique.
  • To utilize an efficient three-dimensional (3D) stack-of-spirals turbo FLASH (SOS-TFL) readout.
  • To achieve rapid, whole-brain, high-resolution T1 quantification.

Main Methods:

  • An IR sequence with multiple inversion times and a short saturation time (Tsat) was employed.
  • A 3D SOS-TFL readout was used for data acquisition.
  • Accuracy was validated using phantoms and in vivo experiments, comparing with a 2D reference and assessing acceleration performance.

Main Results:

  • The 3D SOS-TFL T1 maps showed excellent agreement with the 2D reference.
  • Whole-brain coverage with 1.0-mm isotropic resolution was achieved in 3-4 minutes.
  • Feasibility was demonstrated using moderate undersampling (R=3-4) and through-plane SENSE (R=2).

Conclusions:

  • A fast, whole-brain, high-resolution IR-based T1 mapping method using 3D SOS-TFL was successfully demonstrated.
  • The acquisition was accelerated efficiently without complex undersampling or reconstruction.
  • The method's feasibility and accuracy were confirmed in phantom and human studies.