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High-sensitivity C-reactive protein - a biomarker in stroke subtypes
Nina Camilla Nordly Lauritzen1,2, Lotta Larsson1, Ulriche-Sophie Thiim Pedersen1
1Neurovascular Research Unit, Department of Neurology, Copenhagen University Hospital - Herlev-Gentofte, Copenhagen, Denmark.
Neurological Research
|October 24, 2025
Summary
High-sensitivity C-reactive protein (hs-CRP) levels were higher in cardioembolic stroke patients acutely and at follow-up. Hs-CRP may indicate stroke inflammation but requires more validation for clinical use in stroke classification.
Area of Science:
- Neurology
- Biomarkers
- Inflammation Research
Background:
- Elevated C-reactive protein (CRP) is linked to cardiovascular events and stroke risk factors.
- High-sensitivity CRP (hs-CRP) shows potential for stroke subtype classification, but requires further validation.
- The role of hs-CRP in the chronic phase of stroke is not well understood.
Purpose of the Study:
- To investigate hs-CRP level changes across different ischemic stroke subtypes.
- To assess hs-CRP levels from acute admission to a three-month follow-up.
- To explore the potential of hs-CRP as a biomarker for stroke inflammation and classification.
Main Methods:
- Prospective cohort study including patients with ischemic stroke.
- hs-CRP levels measured on admission and at three-month follow-up.
- Stroke subtypes classified using the Trial of Org 10,172 in Acute Stroke Treatment (TOAST) system.
Main Results:
- Acute phase hs-CRP levels were significantly higher in cardioembolic stroke (CE) compared to small vessel occlusion.
- At three-month follow-up, hs-CRP remained elevated in CE compared to strokes of undetermined etiology.
- Across all stroke subtypes, hs-CRP levels decreased from acute to follow-up, with no significant differences between subtypes.
Conclusions:
- hs-CRP levels differ between ischemic stroke subtypes, notably higher in CE cases during both acute and follow-up phases.
- hs-CRP may serve as a biomarker reflecting stroke-related inflammation.
- Further validation is needed to establish the clinical utility of hs-CRP in stroke subtype classification.
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