Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:03

Long-term Depression

3.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.1K
Long-term Depression01:05

Long-term Depression

33.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase-tuned modulation during reward expectancy in human anterior insular cortex.

Communications biology·2026
Same author

Impact of antiseizure medication taper on electroencephalographic dynamics in focal epilepsy: A stereoelectroencephalographic study.

Epilepsia·2026
Same author

Hippocampal atrophy and functional plasticity underlie cognitive outcome in anti-leucine-rich glioma-inactivated protein 1 encephalitis and their clinical correlates.

Epilepsia·2026
Same author

Delayed excitability recovery and downregulation of neurodevelopmental pathways contribute to phenotypic differences in KCNQ2-related disorders.

Epilepsia·2025
Same author

Familial adult myoclonus epilepsy: A comprehensive diagnostic strategy for clinical practice.

Epilepsia·2025
Same author

Resection of the temporal piriform cortex in mesial temporal lobe epilepsy: Association with seizure freedom in a retrospective cohort study.

Epilepsia·2025
Same journal

Rest-activity patterns across development in two mouse models of autism and epilepsy.

Epilepsia open·2026
Same journal

Utility of repeat stereotactic EEG in pediatric patients with tuberous sclerosis.

Epilepsia open·2026
Same journal

Expanding the electroclinical spectrum of TANC2-related disorders: Lennox-Gastaut syndrome and related developmental epileptic phenotypes.

Epilepsia open·2026
Same journal

Real-world use of Cenobamate in pediatric drug-resistant epilepsy: A European multicenter retrospective study.

Epilepsia open·2026
Same journal

Polypharmacy burden and incident epilepsy among older adults in the United States.

Epilepsia open·2026
Same journal

Relative entropy as a biomarker for vagus nerve stimulation response in epilepsy: Insights from intracerebral electroencephalography.

Epilepsia open·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.5K

Differential glymphatic dysfunction and memory correlation in temporal lobe epilepsy subtypes.

Ruotong Chen1, Hong Li2, Pu Miao3

  • 1Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Epilepsia Open
|October 24, 2025
PubMed
Summary
This summary is machine-generated.

Glymphatic system (GS) impairment, measured by DTI-ALPS, differs between temporal lobe epilepsy subtypes. Reduced GS function in TLE-HS correlates with memory decline, suggesting GS as a therapeutic target for memory enhancement.

Keywords:
glymphatic systemhippocampal sclerosismemoryno lesions on magnetic resonance imagingtemporal lobe epilepsy

More Related Videos

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.8K
Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

11.9K

Related Experiment Videos

Last Updated: Jan 14, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.5K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.8K
Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

11.9K

Area of Science:

  • Neuroimaging
  • Epilepsy Research
  • Cerebrovascular Biology

Background:

  • The glymphatic system (GS) facilitates waste clearance in the brain.
  • Dysfunction of the GS is implicated in various neurological disorders.
  • Temporal lobe epilepsy (TLE) is often associated with cognitive deficits, particularly memory impairment.

Purpose of the Study:

  • To evaluate glymphatic system (GS) function in different temporal lobe epilepsy (TLE) subtypes using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS).
  • To explore the correlation between GS function, clinical factors, and memory performance in TLE patients.

Main Methods:

  • Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) was performed on 112 TLE patients with hippocampal sclerosis (TLE-HS), 73 TLE patients with no lesions (TLE-NL), and 55 healthy controls.
  • Memory performance was assessed using the Wechsler Memory Scale-Revised.
  • Statistical analyses compared DTI-ALPS indices among groups and explored relationships with clinical data and memory outcomes.

Main Results:

  • The TLE-HS group showed significantly lower DTI-ALPS indices in both hemispheres compared to controls.
  • The TLE-NL group exhibited reduced DTI-ALPS indices in the ipsilateral hemisphere only.
  • In TLE-HS patients, the DTI-ALPS index positively correlated with memory performance, and was a significant predictor of memory quotient.
  • Focal to bilateral tonic-clonic seizures in TLE-NL were associated with reduced DTI-ALPS indices in both hemispheres.

Conclusions:

  • Distinct patterns of glymphatic system impairment exist between TLE-HS and TLE-NL.
  • Glymphatic dysfunction is associated with memory deficits in TLE, particularly in TLE-HS.
  • Targeting the glymphatic system may offer a novel therapeutic strategy for memory enhancement in epilepsy.