Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Symbiosis00:58

Symbiosis

36.9K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
36.9K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.5K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD7 drives CD8 T cell exhaustion during chronic viral infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Evaluation and telemetry-based detection of GPS spoofing effects on UAV navigation using software-defined radio.

Scientific reports·2026
Same author

ST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic T<sub>h</sub>1 and T<sub>h</sub>17 programs.

Cell reports·2026
Same author

Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.

The Journal of clinical investigation·2026
Same author

Comparative study of cemented versus screwed prosthesis on the marginal bone stability around dental implants.

Bioinformation·2026
Same author

Malpractice Litigation in Spinal Surgery: Lessons From Real-World Cases and Recommendations for Risk Reduction.

Clinical spine surgery·2025

Related Experiment Video

Updated: Jan 14, 2026

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
05:03

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Published on: April 26, 2024

1.2K

T follicular helper cell development during malaria.

Regina M Antonetti1, Manan Shah1, Noah S Butler2

  • 1Interdisciplinary Immunology Graduate Program, University of Iowa, Iowa City, USA.

Current Opinion in Immunology
|October 24, 2025
PubMed
Summary

Malaria hinders the development of effective immune memory by altering Tfh cell responses. This review explores these unique Tfh cell changes and identifies knowledge gaps for future malaria immunology research.

More Related Videos

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

23.7K
Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.2K

Related Experiment Videos

Last Updated: Jan 14, 2026

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
05:03

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Published on: April 26, 2024

1.2K
High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

23.7K
Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.2K

Area of Science:

  • Immunology
  • Infectious Diseases
  • Parasitology

Background:

  • Malaria affects over 200 million people globally, causing severe illness.
  • CD4 T helper 1 (Th1) and T follicular helper (Tfh) cells are crucial for immunity, but protective memory responses are rare in malaria.
  • Malaria-induced physiological changes may lead to atypical Tfh cell subsets and poor memory.

Purpose of the Study:

  • To review the phenotype and function of Tfh subsets during malaria.
  • To discuss Tfh memory cell development and function in malaria.
  • To identify critical knowledge gaps in malaria-induced Tfh cell responses.

Main Methods:

  • Review of existing literature on Tfh cell differentiation and function in Plasmodium-infected hosts.
  • Analysis of studies investigating malaria-associated environmental cues on Tfh cell populations.
  • Examination of research on Tfh memory cell development during malaria.

Main Results:

  • Malaria infection leads to unique Tfh cell subsets with mixed phenotypes and functions.
  • The development and role of Tfh memory cells in malaria remain poorly understood.
  • Existing knowledge on conventional Tfh cell differentiation in malaria is expanding, but nonconventional subsets are less defined.

Conclusions:

  • Malaria uniquely impacts Tfh cell differentiation and memory formation.
  • Further research is needed to understand nonconventional Tfh subsets and their function in malaria.
  • Addressing knowledge gaps in Tfh cell memory is critical for developing effective malaria vaccines and treatments.