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Updated: May 5, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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Functional pseudo-synapses: A new nexus in extracranial cancer
Xiaofei Zhi1, Puran Zhang2, Timothy C Wang2
1Division of Digestive and Liver Diseases, Irving Cancer Research Center, Columbia University Medical Center, New York City, NY, USA; Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, China.
None:
Functional cancer-to-neuron synapse-like connections are recognized as essential structures and hallmarks of both intracranial and extracranial tumors. In this issue of Cancer Cell, Ren et al. present high-resolution EM structures of pseudo-synaptic connections between sensory nerves and pancreatic ductal adenocarcinoma (PDAC).
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