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Updated: May 1, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Quantitative and Computational Radiobiology for Precision Radiopharmaceutical Therapies
Tahir Yusufaly1, Hamid Abdollahi2, Babak Saboury3
1Department of Radiology and Radiological Sciences, Johns Hopkins, Baltimore, MD, USA.
None:
This article reviews the evolving field of radiobiology, emphasizing the need for advanced multiscale, mechanistic models to optimize radiopharmaceutical therapies (RPTs). While the traditional linear-quadratic model underpins external beam radiation therapy, RPT's unique biological and spatial complexities demand new approaches. First-principles simulations of DNA damage, repair, and multicellular responses are crucial for understanding therapeutic efficacy and toxicity. The integration of these models into personalized, digital twin frameworks promises transformative clinical applications, but progress depends on deep mechanistic insights, experimental validation, and balancing model complexity with practicality for clinical use.
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