Related Experiment Video
Updated: Jan 14, 2026

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
Published on: November 1, 2024
The functional significance of intrinsic disorder in enzymes
Munishwar Nath Gupta1, Vladimir N Uversky2
1Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi, 110016, India.
Abstract:
The role of intrinsic disorder in enzymes has not attracted the attention which it deserves. This perspective discusses how tails and loops in structured proteins, as well as molten globular protein forms, in spite of being disordered, are associated with biocatalysis. Protein kinases illustrate the importance of structural disorder for the function of some enzymes in their native state. Intrinsic disorder actually facilitates moonlighting. Furthermore, disorder-based engineered biomolecular condensates are emerging as enzymatic microreactors.
Related Concept Videos
Intrinsically Disordered Proteins
Intrinsically Disordered Proteins
Enzymes
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Introduction to Mechanisms of Enzyme Catalysis
Introduction to Enzymes
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that...
Protein Denaturation

