Related Experiment Video
Updated: Jan 14, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
Aripiprazole Has Potential Efficacy for Antidepressant-induced Restless Legs Syndrome: A Case Series
Yasuhito Nagai1,2, Koichi Miyakawa1,2
1Department of Psychiatry, Juntendo University Graduate School of Medicine, Tokyo, Japan.
None:
The study aims to report that a lower dose of aripiprazole ameliorates restless legs syndrome (RLS) induced by antidepressants. We report 3 cases of RLS associated with antidepressants. We differentiated the symptoms from akathisia due to diurnal variation and focused sensation in the legs and evaluated them using the International Restless Legs Syndrome Severity Rating Scale. In all cases, the symptoms deteriorated under antidepressant treatment. In one case, this may have been due to discontinuation of aripiprazole. According to the presented cases and literature, we concluded that aripiprazole has efficacy for secondary RLS induced by antidepressants.
Related Concept Videos
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
REM Sleep Behavior Disorder
RBD is significantly associated with...
Antidepressant Drugs: MAOIs and Other Agents
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

