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Intensity-Modulated Proton Therapy for an Unresectable Giant Non-functioning Pituitary Adenoma: A Case Report and
Bo Yan1, Shuihua Wu2, Jiwei Bai3
1Department of Otorhinolaryngology - Head and Neck Surgery, Xuanwu Hospital, Capital Medical University, Beijing, CHN.
Cureus
|October 27, 2025
Summary
Intensity-modulated proton therapy (IMPT) effectively treated a giant, unresectable pituitary adenoma, reducing tumor size and relieving critical structure compression. This advanced radiotherapy offers superior OAR sparing, potentially lowering long-term risks for challenging pituitary adenoma cases.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Medical Physics
Background:
- Giant non-functioning pituitary adenomas (NFPAs) present significant surgical and therapeutic challenges due to their size and proximity to critical structures.
- Conventional radiotherapy may struggle to deliver adequate doses to NFPAs while sparing organs at risk (OARs).
