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Accelerated Hymenoptera testing in pediatric patients.

Elizabeth S Brunner1, Jeffrey M Chambliss1, Timothy G Chow1

  • 1Division of Allergy and Immunology, Department of Pediatrics and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex.

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|October 27, 2025
PubMed
Summary

Accelerated skin testing for Hymenoptera venom allergy is safe for children. This study found no adverse events in pediatric patients undergoing rapid allergy testing for Hymenoptera stings.

Keywords:
HymenopteraVenom hypersensitivitychildrenfire antpediatricsafetyskin testing

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Area of Science:

  • Allergy and Immunology
  • Pediatric Medicine
  • Diagnostic Testing

Background:

  • Hymenoptera sensitization requires skin testing for systemic reactions.
  • Accelerated skin testing protocols exist for adults but lack pediatric data.

Purpose of the Study:

  • To evaluate the safety of an accelerated Hymenoptera skin testing protocol in children.
  • To assess Hymenoptera venom hypersensitivity in pediatric patients.

Main Methods:

  • Retrospective chart review of pediatric patients (2017-2024).
  • Inclusion criteria: history of systemic reaction to Hymenoptera sting, completed allergy testing.
  • Data collected: demographics, reaction/testing age, atopy, severity, testing details.

Main Results:

  • 61 pediatric patients included; 80% had moderate to severe reactions (Mueller grade 2-4).
  • 36 patients received accelerated intradermal testing (flying Hymenoptera or fire ant).
  • No adverse events or systemic reactions occurred during accelerated testing.

Conclusions:

  • Accelerated Hymenoptera skin testing appears safe in the pediatric population.
  • Further multicenter studies are recommended to confirm safety and efficacy.