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Drug Anaphylaxis
Timothy G Chow1, Anna Cheng1, Cynthia Haddad1
1Division of Allergy and Immunology, Departments of Internal Medicine and Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard F04.206, Dallas, TX 75390-9063, USA.
Immunology and Allergy Clinics of North America
|April 3, 2026
Summary
Drug-induced anaphylaxis (DIA) is a severe allergic reaction. This review covers its epidemiology, features, mechanisms, evaluation, and management, highlighting recent advances in understanding its diverse causes and presentations.
Area of Science:
- Clinical Immunology
- Allergy and Immunology
- Pharmacology
Background:
- Anaphylaxis is a rapid, systemic allergic reaction triggered by various agents.
- Drugs are a common cause of anaphylaxis, necessitating a deeper understanding of drug-induced anaphylaxis (DIA).
Purpose of the Study:
- To provide a comprehensive review of drug-induced anaphylaxis (DIA).
- To discuss the epidemiology, clinical manifestations, underlying mechanisms, diagnostic approaches, and therapeutic strategies for DIA.
Main Methods:
- Literature review focusing on recent advancements in understanding DIA.
- Synthesis of current knowledge on DIA pathophysiology, clinical presentation, and management.
Main Results:
- Recognition of multiple endotypes contributing to the anaphylaxis phenotype.
- Increased nuance in understanding the diverse triggers and mechanisms of DIA.
Conclusions:
- Effective management of DIA requires understanding its complex etiology and varied clinical presentations.
- Continued research into DIA endotypes will refine diagnostic and therapeutic approaches.
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