Mycoplasma pneumoniae-Associated Mucositis: A Diagnostic Dilemma

Fuchs syndrome is a mucosal variant of Stevens-Johnson syndrome (SJS) without cutaneous lesions, mostly affecting the mucosa of the mouth, conjunctiva, and genitalia, that occurs in a background of Mycoplasma pneumoniae and herpes simplex infection. Treatment with antibiotics such as macrolides, tetracycline, or fluoroquinolones has been shown to limit the pulmonary disease, but it is unclear whether the incidence or severity of the mucocutaneous eruption is reduced. In the absence of cutaneous manifestations, the patient often seeks multiple specialists, including ophthalmologists, dentists, otolaryngologists, gynecologists, or urologists, so a suspicion of Mycoplasma in such cases can avoid delay in diagnosis and adverse sequelae. We hereby report a case of Mycoplasma pneumoniae-associated Fuchs syndrome which showed significant improvement with oral antibiotics.