Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

20.6K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
20.6K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

576
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
576
Synthetic Biology02:55

Synthetic Biology

5.5K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.5K
Nucleic acids02:43

Nucleic acids

188.2K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
188.2K
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

503
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
503

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Angiogenin mediates cell-cell fusion as a mitochondrial RNA processing enzyme.

Bone research·2026
Same author

A spatially confined "double-key lock" smart DNA hydrogel for dynamic detection of MicroRNA in cells.

Chemical science·2026
Same author

Perioperative interventions in preventing postoperative delirium following orthopaedic surgery in the elderly: a Bayesian network meta-analysis.

Journal of orthopaedic translation·2026
Same author

Application of bulbospongiosus muscle flap tamponade combined with vaginal occlusion in the repair of complex urinary fistula following radiotherapy: a surgical technique.

Gynecology and pelvic medicine·2026
Same author

Nox4 mediates chondrocyte senescence and cartilage degradation in post-traumatic osteoarthritis via the ROS/p38MAPK signaling pathway.

International immunopharmacology·2026
Same author

Three-Dimensional In Situ Sensing and Spatiotemporal Imaging Analysis of Dual Targets in Steatotic Liver Disease.

Analytical chemistry·2026
Same journal

From cyclic diaryl λ<sup>3</sup>-bromanes/chloranes to polyfuntionalized biarylsilanes <i>via</i> aryne σ-bonds.

Chemical science·2026
Same journal

Non-equilibrium formation of the elusive dibridged diboranyl (B<sub>2</sub>H<sub>5</sub>) radical and boranes in low-temperature diborane ices.

Chemical science·2026
Same journal

Visible-light-driven ruthenium-catalyzed hydrogenation of manganese nitride complexes to ammonia under ambient conditions.

Chemical science·2026
Same journal

Quantification of mesopore infiltration in a polymer-grafted metal-organic framework.

Chemical science·2026
Same journal

Enhanced and selective oxygen reduction by iron porphyrin with a biguanide residue in the second coordination sphere.

Chemical science·2026
Same journal

Excited-state orbital angular momentum enables all-optical molecular spin coherence.

Chemical science·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.8K

Intelligent molecular logic computing toolkits: nucleic acid-based construction, functionality, and enhanced

Yaxue Hu1, Jinghui Zhang1, Ke Shen1

  • 1School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology Zhenjiang 212003 Jiangsu PR China jinghui_zhang@just.edu.cn tangsheng.nju@gmail.com chmts@just.edu.cn.

Chemical Science
|October 27, 2025
PubMed
Summary
This summary is machine-generated.

Molecular logic computing enhances biosensing with intelligent, programmable detection using biological molecules. These advanced toolkits enable complex information processing for applications from genetic analysis to point-of-care diagnostics.

More Related Videos

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

12.8K
Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

15.0K

Related Experiment Videos

Last Updated: Jan 14, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.8K
Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

12.8K
Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

15.0K

Area of Science:

  • Biotechnology and Biomedical Engineering
  • Molecular Computing
  • Biosensing Technologies

Background:

  • Molecular logic computing is transforming biosensing beyond simple detection.
  • Biological molecules like DNA, RNA, proteins, and cells are used to build logic toolkits.
  • This approach enables advanced molecular-level information processing.

Purpose of the Study:

  • To provide a comprehensive review of intelligent molecular logic operation toolkits.
  • To detail their design principles, construction, and functionalities in biosensing.
  • To highlight applications and future challenges in the field.

Main Methods:

  • Review of design principles for various logic gates (Boolean, combinatorial, sequential, fuzzy, reversible).
  • Exploration of DNA-based, synthetic, and nanomaterial-based toolkit construction.
  • Analysis of detection platforms (fluorescent, colorimetric, electrochemical, AI, smartphone-based).

Main Results:

  • Molecular logic toolkits offer modular multi-signal integration and reconfigurable control.
  • They enable programmable control and logic-gated nanomachines for complex tasks.
  • Applications include genetic analysis, cancer detection, pathogen identification, and point-of-care diagnostics.

Conclusions:

  • Molecular logic computing significantly advances biosensing capabilities.
  • Challenges remain in practical implementation and future development.
  • Continued research promises enhanced biosensing and diagnostic tools.