Related Experiment Video
Updated: Jan 14, 2026

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
Catalytic Ullmann-Type N-Arylation to Access Medicinally Important SuFEx-able Pyrazolo[1,5-a]Quinoxalinones
Bipin Khanal1, Kanokwan Jaithum2, Mark Aldren M Feliciano3
1Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003, USA.
Abstract:
Pyrazole-fused quinoxalines provide an attractive structural motif for medicinal chemistry and have inspired the development of novel synthetic methods. This work details a concise methodology for the synthesis of a new class of pyrazolo[1,5-a]quinoxaline-4-ones, where the incorporation of a sulfonyl fluoride enables sulfur(IV) fluoride exchange (SuFEx) chemistry. This synthetic approach opens the door for the rapid diversification of these fused heterocycles, providing a powerful strategy for the expansion of chemical space and the development of novel bioactive compounds.
Related Concept Videos
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism
Nucleophilic Aromatic Substitution: Elimination–Addition
Preparation of Nitriles

