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Efficacy of Endoscopic Full Thickness Resection Using the Full-Thickness Resection Device for Submucosal Invasive
Rahul Karna1, Syed Kashif Mahmood2, Jennifer Phan3
1Division of Gastroenterology & Hepatology, University of Minnesota Medical Center, Minneapolis, MN, USA.
Digestive Diseases and Sciences
|October 27, 2025
Summary
Endoscopic full-thickness resection (EFTR) shows promise for colorectal submucosal invasive cancer (SMIC). This study found high technical success and R0 resection rates, though further research is needed.
Area of Science:
- Gastroenterology
- Endoscopic Surgery
- Oncology
Background:
- Endoscopic full-thickness resection (EFTR) is utilized for non-lifting or previously manipulated polyps.
- Limited data exists on EFTR efficacy for colorectal submucosal invasive cancer (SMIC).
Purpose of the Study:
- To evaluate the efficacy of EFTR using a full thickness resection device for colorectal SMIC.
- To assess technical success, resection rates, and adverse events associated with EFTR for SMIC.
Main Methods:
- A retrospective, multicenter study was conducted.
- Patients undergoing EFTR with a full thickness resection device for suspected or biopsy-proven colorectal cancer (CRC) were included.
Main Results:
- Technical success rate was 100% with an 85% R0 resection rate.
- 46.7% curative resection rate was observed in T1 CRC patients (7/15).
- Adverse events included bleeding, perforation, and post-polypectomy syndromes, mostly managed conservatively or endoscopically.
Conclusions:
- This study presents the first US multicenter experience with EFTR for colorectal SMIC.
- Larger-scale longitudinal studies are necessary to confirm the initial findings and validate EFTR for SMIC treatment.
