Endoscopic Ablation for Malignant Lung Lesions: Current Techniques, Unmet Needs, and Future Directions

Area of Science:

• Pulmonology
• Oncology
• Medical Technology

Background:

• Lung cancer is a leading cause of cancer mortality globally.
• Current treatments like surgery and radiation have limitations for early-stage or high-risk patients.
• Endoscopic ablation emerges as a minimally invasive alternative for targeting lung lesions.

Purpose of the Study:

• To review current evidence on endoscopic ablation techniques for lung cancer.
• To focus on emerging technologies, clinical applications, and research gaps.
• To synthesize information on the safety and efficacy of endoscopic ablation.

Main Methods:

• Review of current literature on endoscopic ablation for lung cancer.
• Analysis of various endoscopic ablation modalities (radiofrequency, microwave, laser, etc.).
• Examination of technological advancements like robotic bronchoscopy and cone-beam CT.

Main Results:

• Endoscopic ablation techniques allow precise, localized therapy delivery via bronchoscopy.
• Early data indicate high technical success and favorable short-term safety.
• Potential for immunologic synergy when combined with systemic therapies.

Conclusions:

• Endoscopic ablation is a promising, lung-sparing treatment for lung malignancies.
• Technological advancements are improving precision and therapeutic reach.
• Large prospective trials are necessary to validate oncologic efficacy and establish its role in multimodal therapy.