Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Breast cancer is a leading global health concern with persistent treatment challenges.
• Limitations of traditional therapies include drug resistance, metastasis, and side effects.
• Nanozymes, nanomaterials with enzyme-like activity, present novel therapeutic avenues.

Purpose of the Study:

• To review nanozyme applications in breast cancer treatment.
• To explore nanozymes' role in improving immunotherapy, chemotherapy, and combination therapies.
• To analyze challenges and prospects for nanozyme clinical translation.

Main Methods:

• Literature review of nanozyme applications in breast cancer.
• Analysis of nanozyme mechanisms in modulating the tumor microenvironment.
• Evaluation of nanozymes in drug delivery, resistance overcoming, and combined therapies.

Main Results:

• Nanozymes can enhance immunotherapy by regulating the tumor microenvironment and immune response.
• They optimize chemotherapy through improved drug delivery and overcoming resistance.
• Nanozymes facilitate enhanced efficacy in photothermal/photodynamic combination therapies.

Conclusions:

• Nanozymes show significant potential for precise, efficient, and low-toxicity breast cancer treatment.
• Addressing challenges like biocompatibility and scalability is crucial for clinical translation.
• Combining nanozymes with existing strategies offers promising future directions for breast cancer therapy.