Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Patterns of Fever01:26

Patterns of Fever

3.8K
Before understanding the types and patterns of fever, it is essential to know its phases.
3.8K
Disorders of Leukocytes01:27

Disorders of Leukocytes

1.8K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.8K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

543
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
543
Increased Body Temperature01:25

Increased Body Temperature

6.4K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
6.4K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.9K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.9K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.9K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Intravascular large B-cell lymphoma of the nasal turbinate presenting with hemophagocytic lymphohistiocytosis: a case report and literature review].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2025
Same author

[The influence of preoperative CT image characteristics on the outcome of thoracoscopic surgery for chronic tuberculous empyema].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2025
Same author

Effect and mechanism of recombinant human fibroblast growth factor 18 on osteoporosis in OVX mice.

Climacteric : the journal of the International Menopause Society·2024
Same author

[Value of (18)F-FDG PET-CT imaging to predict epidermal growth factor receptor mutations in patients with lung squamous cell carcinoma].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2021
Same author

[Clonal-related transformation from Waldenström macroglobulinemia to diffuse large B cell lymphoma during the treatment of ibrutinib: a case report and literature review].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2020
Same author

[Prognostic value of bone marrow (18)F-FDG uptake pattern of pretreatment PET-CT in extranodal NK/T cell lymphoma].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2020

Related Experiment Video

Updated: Jan 14, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.8K

[Recurrent fever, persistent cytopenia].

Y Miao1, J Zhang2, H Zhang3

  • 1Department of Hematology, Lymphoma Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Department of Oncology, Department of Hematology, Affiliated Hospital of Nantong University, Nantong 226001, China.

Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
|October 27, 2025
PubMed
Summary

Intravascular large B-cell lymphoma (IVLBCL) is a rare cancer. This case highlights the diagnostic challenges and aggressive nature of IVLBCL, emphasizing the need for multidisciplinary collaboration in diagnosis and treatment.

More Related Videos

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

30.4K
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.6K

Related Experiment Videos

Last Updated: Jan 14, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.8K
Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

30.4K
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.6K

Area of Science:

  • Hematology
  • Oncology
  • Rare Diseases

Background:

  • Intravascular large B-cell lymphoma (IVLBCL) is an uncommon subtype of large B-cell lymphoma.
  • Patients often present with non-specific symptoms, complicating early diagnosis.

Purpose of the Study:

  • To report a challenging case of IVLBCL initially misdiagnosed.
  • To underscore the importance of a multidisciplinary approach in diagnosing and managing IVLBCL.
  • To provide insights for clinical practice regarding IVLBCL diagnosis and treatment.

Main Methods:

  • Case report of a 64-year-old female with a history of Waldenstrom's macroglobulinemia.
  • Utilized positron emission tomography/computed tomography (PET/CT) and adrenal biopsy for diagnosis.
  • Treatment involved R-CHOP chemotherapy followed by identification of central nervous system (CNS) involvement.
  • Diagnosis was revised to IVLBCL after adrenal biopsy review.

Main Results:

  • The patient initially presented with recurrent fever and pancytopenia.
  • Adrenal gland enlargement was detected on PET/CT, leading to an initial diagnosis of diffuse large B-cell lymphoma, not otherwise specified.
  • CNS infiltration was identified after initial chemotherapy.
  • The final diagnosis was confirmed as IVLBCL, but the disease progressed despite aggressive treatment, leading to the patient's death.

Conclusions:

  • IVLBCL poses significant diagnostic challenges due to its rarity and non-specific presentation.
  • Multidisciplinary collaboration involving imaging, pathology, and clinical expertise is crucial for accurate IVLBCL diagnosis.
  • The aggressive nature of IVLBCL necessitates prompt and appropriate management strategies, though outcomes remain poor in many cases.