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m7G-related gene signatures determine prognosis in triple-negative breast cancer

Yunxiang Li1, Xin Lan2, Jianqiao Dong2

  • 1Department of Breast Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Scientific Reports
|October 28, 2025
PubMed

Insights

This study identifies m7G modifications as key in triple-negative breast cancer (TNBC) prognosis. A novel risk model stratifies patients, guiding personalized therapies and improving survival predictions for this challenging cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Triple-negative breast cancer (TNBC) presents a significant clinical challenge due to a lack of targeted therapies.
  • Understanding the molecular drivers and prognostic factors in TNBC is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the role of m7G modifications in TNBC.
  • To develop a prognostic risk model based on m7G-related genes.
  • To explore the relationship between m7G modifications, the tumor immune microenvironment, and patient survival.

Main Methods:

  • Integrated analysis of m7G-related genes in TNBC.
  • Development of a risk stratification model.
  • Analysis of immune cell infiltration and genomic mutations.
  • Chemosensitivity profiling and nomogram construction.

Main Results:

  • A risk model based on differentially expressed m7G-related genes effectively stratified TNBC patients into low- and high-risk groups with distinct survival outcomes.
  • Significant differences in immune cell infiltration were observed between risk groups.
  • Distinct genomic mutation patterns, including TP53 and PIK3CA, were associated with risk groups.
  • The risk score showed potential for predicting chemosensitivity and was incorporated into a nomogram for survival prediction.

Conclusions:

  • m7G modifications are significantly associated with TNBC prognosis and the tumor immune microenvironment.
  • The developed m7G-related risk score serves as a valuable tool for patient stratification and personalized treatment strategies in TNBC.
  • A predictive nomogram incorporating the risk score offers improved accuracy for long-term survival probability estimation in TNBC patients.
Keywords:
Immune microenvironmentPrognosisTriple-negative breast cancerTumor mutational burdenm7G modification

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