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Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

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Related Experiment Video

Updated: Jan 14, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

Author Correction: Peptide design through binding interface mimicry with PepMimic

Xiangzhe Kong^1,2, Rui Jiao^1,2, Haowei Lin^3,4

¹Department of Computer Science and Technology, Tsinghua University, Beijing, China.

Nature Biomedical Engineering

|October 28, 2025

Summary

No abstract available in PubMed .

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