Correlation of inflammatory burden index with 30-day readmission rates in patients post-elective percutaneous...

The 30-day readmission rate post-percutaneous coronary intervention (PCI) is a critical quality metric, yet the factors influencing this outcome are not fully understood. We aimed to investigate the association between the Inflammatory Burden Index (IBI), a composite inflammatory biomarker, and 30-day readmission following PCI.

We conducted a retrospective cohort study from patients who underwent elective PCI from January 2020 to December 2024. The primary outcome was the incidence of 30-day hospital readmission post-PCI. The IBI was calculated using C-reactive protein (CRP), neutrophil count, and lymphocyte count. We performed univariate and multivariate logistic regression analyses to assess the association between IBI and 30-day readmission. Subgroup analyses were conducted to explore the impact of demographic and clinical factors on this association.

A total of 1,200 patients were included in final analysis. The mean age was 62.5 years, and 68% were male. The 30-day readmission rate was 16.2%. Higher IBI was significantly associated with 30-day readmission in both univariate (OR: 1.45, 95% CI:1.26-1.67, p < 0.001) and multivariate (OR 1.41, 95% CI 1.19-1.67, p < 0.001) analyses. Subgroup analyses revealed that the association was particularly pronounced in older, male patients and those with diabetes. Sensitivity and competing risks analyses confirmed the robustness of our findings.

Higher IBI is significantly correlated with 30-day readmission following elective PCI, independent of traditional risk factors. These results suggest that IBI may serve as a valuable tool for identifying patients at increased risk of readmission, potentially guiding the development of targeted post-discharge strategies to reduce readmission rates.