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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Contrast-Enhanced Mammography: Advances, Challenges, and Case-Based Insights.

Noam Nissan1, Janice S Sung2

  • 1Department of Radiology, Sheba Medical Center, Ramat Gan, Israel.

Korean Journal of Radiology
|October 28, 2025
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Summary
This summary is machine-generated.

Contrast-enhanced mammography (CEM) improves breast lesion detection and characterization. This review focuses on practical, case-based insights for integrating CEM into clinical practice and optimizing breast imaging strategies.

Keywords:
Background parenchymal enhancementBreast MRIContrast-enhanced mammographyDense breastSupplementary screening

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Area of Science:

  • Radiology
  • Medical Imaging
  • Oncology

Background:

  • Contrast-enhanced mammography (CEM) is a vital breast imaging tool.
  • It combines anatomical and functional information for enhanced lesion detection and characterization.

Purpose of the Study:

  • To review recent advances in CEM technology.
  • To explore expanding clinical applications of CEM.
  • To discuss interpretation pitfalls and limitations of CEM.

Main Methods:

  • Focus on a case-based perspective for emerging applications.
  • Provide practical insights for clinical integration.
  • Illustrate CEM's role in optimizing breast imaging strategies.

Main Results:

  • Recent advances in CEM technology have been highlighted.
  • Expanding clinical applications are explored.
  • Common interpretation pitfalls and limitations are discussed.

Conclusions:

  • CEM effectively complements other imaging modalities.
  • It offers practical insights for routine and complex diagnostic scenarios.
  • CEM can be efficiently incorporated into clinical practice.