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Three Cases of Advanced Melanoma With Severe irAE Colitis With Rapid Tumor Progression Following Infliximab
Emi Yamazaki1, Taku Fujimura1, Yumi Kambayashi1
1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Abstract:
Immune checkpoint inhibitors (ICIs) have improved melanoma outcomes but can cause severe immune-related colitis. Infliximab is often used for steroid-refractory cases, yet its effect on tumor control remains uncertain. We describe three advanced melanoma patients who developed grade 3-4 colitis after nivolumab plus ipilimumab and were treated with infliximab. Although gastrointestinal symptoms improved, all showed rapid disease progression and died within 3-9 months. These cases suggest that infliximab may compromise antitumor immunity in melanoma patients receiving ICIs.
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