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  3. Modularly Designed Transformable Peptides For Morphological Control And Biomedical Applications.
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  3. Modularly Designed Transformable Peptides For Morphological Control And Biomedical Applications.

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Modularly Designed Transformable Peptides for Morphological Control and Biomedical Applications.

Si Sun1, Jianli Zuo2,3, Yu Zuo1

  • 1National Engineering Research Center of Immunological Products, Third Military Medical University, 30 Gaotanyan Zheng Street, Shapingba District, Chongqing, 400038, China.

Chembiochem : a European Journal of Chemical Biology
|October 28, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Transformable peptides self-assemble into nanostructures for targeted disease treatment. These adaptable biomaterials show promise for advancing clinical applications in diagnostics and therapeutics.

Keywords:
biomaterialsbiomedicinenanostructuresself‐assemblytransformable peptides

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Chemical Biology

Background:

  • Transformable peptides exhibit unique structural tunability and modularity.
  • They self-assemble into diverse nanostructures with tunable physicochemical properties.
  • Research is progressing towards clinical translation of self-assembling peptides.

Purpose of the Study:

  • To systematically review peptide building blocks and self-assembly mechanisms.
  • To explore factors influencing nanostructure formation and transformation.
  • To highlight biomedical applications of transformable peptide nanostructures.

Main Methods:

  • Review of molecular design principles for self-assembling peptides.
  • Analysis of noncovalent interactions driving peptide self-assembly.
  • Summary of key factors governing peptide nanostructure transformation.

    • Main Results:

    • Peptide self-assembly is guided by intermolecular forces and molecular design.
    • Diverse nanostructures arise from controlled peptide assembly.
    • Transformable peptides offer precise targeting for disease intervention.

    Conclusions:

    • Transformable peptides are promising biomaterials for biomedicine.
    • Their applications span disease imaging, cancer therapy, and antimicrobial treatments.
    • These materials hold significant potential for clinical translation.