Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Whole Body Regeneration

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Antler stem cells effectively alleviate the symptoms of cerebral ischemic injury via immunomodulation of the spleen.

Cell death discovery·2026

Same author

Acoel whole-body regeneration begins with spreading, multi-tissue ERK signaling downstream of <i>neuregulin-1</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

A new perspective on mesenchymal stem cells and their derivatives in alleviating cerebral ischemia-reperfusion injury dynamically regulating mitochondrial function to remodel the immune network.

Cell death & disease·2026

Same author

p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials.

Cell death discovery·2026

Same author

Developmental, regenerative, and behavioral dynamics in acoel reproduction.

eLife·2026

Same author

A vast stem-progenitor cell pool, richly vascular system, and hybrid ossification drive the daily centimeter-scale elongation of bony antlers.

iMeta·2025

Same journal

PBX-dependent and -independent Hox programs establish and maintain motor neuron terminal identity.

Development (Cambridge, England)·2026

Same journal

NUDT21 regulates 3'UTR dynamics in epididymal principal cells to preserve sperm integrity.

Development (Cambridge, England)·2026

Same journal

Cell size control emerges from the vein-dependent coordinated divisions of distinct cell groups in Drosophila wing.

Development (Cambridge, England)·2026

Same journal

The people behind the papers - Kaoru Sugimura.

Development (Cambridge, England)·2026

Same journal

The people behind the papers - Zhainib Amir-Ugokwe and Kristy Red-Horse.

Development (Cambridge, England)·2026

Same journal

In preprints: toward a holistic lineage-tracing map of mammalian embryogenesis.

Development (Cambridge, England)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 13, 2026

Methods for the Study of Regeneration in Stentor

Methods for the Study of Regeneration in Stentor

Published on: June 13, 2018

More extraordinary model systems for regeneration.

José E García-Arrarás¹, Chunyi Li², Tania Rozario³

¹Biology Department, University of Puerto Rico, Box 23360, UPR Station, San Juan, PR 00936, USA.

Development (Cambridge, England)

|October 28, 2025

Summary

This summary is machine-generated.

Organisms can regenerate lost body parts, a phenomenon studied in various species. This research explores unique regenerative capabilities across diverse life forms, from plants to vertebrates.

More Related Videos

Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica

Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica

Published on: August 31, 2011

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Published on: July 12, 2019

Related Experiment Videos

Last Updated: Jan 13, 2026

Methods for the Study of Regeneration in Stentor

Methods for the Study of Regeneration in Stentor

Published on: June 13, 2018

Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica

Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica

Published on: August 31, 2011

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Published on: July 12, 2019

Area of Science:

Regenerative Biology
Developmental Biology
Comparative Biology

Background:

Organismal regeneration is a long-standing biological fascination.
Previous work highlighted well-studied model organisms and lesser-known species with regenerative potential.
Extraordinary regenerative abilities exist across diverse taxa, from plants to vertebrates.

Purpose of the Study:

To revisit the topic of organismal regeneration.
To present expert perspectives on species with remarkable regenerative potential.
To explore lesser-known examples of regeneration in biology.

Main Methods:

Expert interviews and perspectives.
Review of existing literature on regenerative species.
Comparative analysis of regenerative mechanisms across different organisms.

Main Results:

Five experts share insights into species with unique regenerative abilities.
The study highlights diverse examples of regeneration beyond commonly studied models.
Regenerative potential varies significantly across the tree of life.

Conclusions:

Understanding regeneration requires studying a wide array of species.
Lesser-known organisms offer valuable insights into regenerative processes.
Further research into diverse regenerative systems can advance the field.