Related Experiment Video

Updated: Jan 13, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Patient-Stakeholder Engagement for Patient-Centered Research on Sleep Apnea

Sairam Parthasarathy1,2, Gilles Frydman3

  • 1University of Arizona Center for Sleep, Circadian, and Neuroscience Research, University of Arizona, Tucson.

NEJM Evidence
|October 28, 2025
PubMed

Insights

Patient-led research can improve adherence to continuous positive airway pressure (CPAP) therapy for sleep apnea. Engaging patients in trial design enhances research outcomes and public health benefits.

Area of Science:

  • Sleep Medicine
  • Clinical Trials
  • Cardiovascular Disease

Background:

  • A 2016 trial found continuous positive airway pressure (CPAP) did not reduce cardiovascular events in sleep apnea patients.
  • CPAP nonadherence was suspected as a reason for the trial's negative results, highlighting a need for new strategies.

Purpose of the Study:

  • To describe the design of a clinical trial evaluating a peer-support strategy for improving CPAP adherence.
  • To emphasize the role of patients as drivers of research ideas and their impact on trial success.

Main Methods:

  • The study details the design of a clinical trial focused on a peer-support intervention.
  • Patient-stakeholder committees were integral to the research process, guiding trial development.

Main Results:

  • Patient engagement in research design can yield significant returns on investment.
  • This patient-centered approach can help clinical trials achieve their objectives for chronic conditions.

Conclusions:

  • Empowering patients in clinical trial design is crucial for addressing challenges like CPAP nonadherence.
  • Patient-engaged research offers a roadmap for improving trial success and public health outcomes in sleep apnea and other chronic diseases.

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