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Motor and Cognitive Fatigue in Chronic Inflammatory Demyelinating Polyneuropathy
Oliver L Steiner1,2,3, Claudia Angela1,2, Rohat Geran1
1Department of Neurology, Motor and Cognition Group, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
European Journal of Neurology
|October 28, 2025
Summary
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) significantly impacts patients with both motor and cognitive fatigue. These non-sensorimotor symptoms are crucial aspects of the disease burden, extending beyond physical disability.
Area of Science:
- Neurology
- Immunology
- Psychology
Background:
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a primary dysimmune neuropathy affecting sensorimotor nerves.
- Emerging evidence suggests CIDP involves non-sensorimotor symptoms (NSMS), challenging its purely peripheral classification.
- Fatigue is a prominent NSMS in CIDP, necessitating differentiation between its motor and cognitive components.
Purpose of the Study:
- To differentiate the motor and cognitive components of fatigue in CIDP patients.
- To investigate the relationship between fatigue, sensorimotor disability, and psychological factors.
- To explore the potential role of serum neurofilament light chain (sNfL) as a biomarker for fatigue in CIDP.
Main Methods:
- Assessed motor and cognitive fatigue using the Fatigue Scale for Motor and Cognitive Functions (FSMC) in 47 CIDP patients and 31 healthy controls (HC).
- Correlated fatigue scores with measures of sensorimotor disability, depressiveness, sleep quality, and alertness.
- Analyzed fatigue in relation to serum neurofilament light chain (sNfL) levels.
Main Results:
- CIDP patients exhibited significantly higher total, motor, and cognitive fatigue scores than HC.
- Motor fatigue was more pronounced than cognitive fatigue in the CIDP group.
- Functional disability and depressiveness predicted both fatigue components, while sNfL showed no significant association with fatigue.
Conclusions:
- The impact of CIDP extends beyond sensorimotor deficits, with significant motor and cognitive fatigue components.
- Fatigue, encompassing both motor and cognitive dimensions, represents a clinically relevant NSMS in CIDP.
- Understanding these NSMS is vital for a comprehensive assessment of CIDP's burden.
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