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Lymphocyte transformation in immunoproliferative disorders.

D Catovsky, P J Holt, D A Galton

    British Journal of Cancer
    |June 1, 1972
    PubMed
    Summary

    Lymphocyte transformation is reduced in lymphoproliferative disorders like chronic lymphocytic leukemia (CLL) and follicular lymphoma (FLL), but normal in plasma cell disorders. Abnormal circulating cells may explain these findings in certain immunoproliferative conditions.

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    Area of Science:

    • Immunology
    • Hematology
    • Cell Biology

    Background:

    • Immunoproliferative disorders encompass lymphoproliferative and plasma cell neoplasms.
    • Assessing lymphocyte function is crucial for understanding these conditions.

    Purpose of the Study:

    • To investigate lymphocyte transformation in response to phytohaemagglutinin (PHA) in patients with immunoproliferative disorders.
    • To correlate in vitro lymphocyte behavior with disease characteristics.

    Main Methods:

    • Lymphocyte transformation assays using PHA were performed on 30 patients.
    • Long-term in vitro lymphocyte survival was assessed in a subset of patients.

    Main Results:

    • Reduced PHA-induced lymphocyte transformation was observed in chronic lymphocytic leukemia (CLL), follicular lymphoma (FLL), and Waldenström's macroglobulinaemia (WM).
    • Normal transformation occurred in plasma cell disorders and idiopathic cold haemagglutinin disease.
    • Abnormal lymphocytes in circulation correlated with reduced transformation in CLL, FLL, WM, and plasma cell leukemia.
    • PHA-non-responsive lymphocytes from CLL and FLL showed prolonged in vitro survival, suggesting in vivo longevity.

    Conclusions:

    • Circulating abnormal lymphocytes contribute to impaired PHA response in certain immunoproliferative disorders.
    • The long in vitro survival of non-responsive lymphocytes in CLL may reflect their extended lifespan in vivo.
    • Disease activity in WM correlates with blast transformation levels.

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