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Trends and Hot Spots in Research Related to Rivaroxaban: Bibliometric Analysis
Kornel Pawlak1,2, Łukasz Kruszyna3, Anna Wesołowska4
1Department of Physical Pharmacy & Pharmacokinetics, Poznan University of Medical Sciences, Rokietnicka Street 3, 60-806 Poznan, Poland.
Clinics and Practice
|October 28, 2025
Summary
This bibliometric analysis highlights growing research on rivaroxaban, a direct-acting oral anticoagulant (DOAC). Key trends include comparing DOACs with warfarin and exploring safety in various medical conditions.
Area of Science:
- Pharmacology and Thrombosis Research
- Bibliometrics and Scientometrics
Background:
- Increasing publication volume on rivaroxaban presents review challenges for researchers.
- Bibliometric analysis is crucial for navigating the expanding body of scientific literature.
Purpose of the Study:
- To identify emerging trends and research hotspots in rivaroxaban studies.
- To provide guidance for future research directions in anticoagulation therapy.
Main Methods:
- Analysis of 6979 articles from Web of Science (1991-2024).
- Utilized VOSviewer and Microsoft Excel for data processing and visualization.
- Constructed bibliometric maps based on co-citations and keyword co-occurrences.
Main Results:
- Research interest peaked in 2021, followed by a decline.
- Emerging trends focus on comparing NOACs (novel oral anticoagulants) with warfarin, exploring new NOACs, and assessing therapy safety.
- Trending topics include ABCB1, peripheral artery disease, direct-acting oral anticoagulants, PCI, and SARS-CoV-2.
Conclusions:
- Rivaroxaban research increasingly focuses on medical conditions treated and therapy safety.
- Bibliometric insights guide future research on anticoagulation strategies and patient outcomes.
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