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Updated: Jan 13, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
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Chronic Hepatitis B: Current Management and Future Directions

Hamza Ertugrul1, Esra Ekiz1, Sibel Islak Mutcali2

  • 1Trinity Health of New England, St. Mary's Hospital, 56 Franklin Street, Waterbury, CT 06706, USA.

Diseases (Basel, Switzerland)
|October 28, 2025
PubMed

Insights

Chronic hepatitis B (CHB) management faces challenges due to persistent virus, despite existing treatments. New therapies aim for a functional cure by targeting viral reservoirs and enhancing immunity.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Chronic hepatitis B virus (HBV) infection is a significant global health issue causing liver disease.
  • Current treatments like nucleos(t)ide analogs and interferon suppress HBV but do not offer a cure.
  • Persistent covalently closed circular DNA (cccDNA) prevents complete viral eradication.

Purpose of the Study:

  • To review current therapeutic strategies for chronic hepatitis B (CHB).
  • To summarize recent advancements in CHB treatment.
  • To explore emerging directions for achieving a functional cure for CHB.

Main Methods:

  • Literature review of current and emerging CHB therapies.
  • Analysis of research on novel antiviral agents and immunomodulatory treatments.
  • Synthesis of data on combination strategies for HBV management.

Main Results:

  • Existing therapies improve viral suppression and delay disease progression.
  • Novel agents and immunotherapies show promise in research settings.
  • Combination strategies are being investigated for enhanced efficacy.

Conclusions:

  • A functional cure for CHB remains a key goal.
  • New therapeutic avenues are crucial for overcoming treatment limitations.
  • Continued research into novel agents and combination therapies is essential for advancing CHB management.

Keywords:
HBsAg release inhibitorscapsid assembly modulators (CAMs)covalently closed circular DNA (cccDNA)farnesoid X receptor (FXR) agonistsfunctional curehepatitis B virus (HBV)nucleot(s)ide analogs (NAs)pegylated interferon alpha (PegIFNα)

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