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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Composite Hydrogels with Embedded Electrospun Fibers as Drug Delivery Systems.

Paul Codrin Fuioaga1,2, Delia Mihaela Rata2, Tabinda Riaz3

  • 1"Cristofor Simionescu" Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 700050 Iasi, Romania.

Gels (Basel, Switzerland)
|October 28, 2025
PubMed
Summary

Hydrogel/electrospun polymer nanofiber composites (HENC) combine hydrogels and nanofibers for advanced drug delivery. These biomimetic materials offer tunable release and mimic native tissues, showing great potential for therapeutic applications.

Keywords:
3D printingcompositeselectrospinninghydrogelsmultilayer

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Hydrogels offer high water content and biocompatibility.
  • Electrospun nanofibers provide high surface area and tunable morphology.
  • Combining these creates advanced composite materials.

Purpose of the Study:

  • To review the fundamentals, preparation, and applications of hydrogel/electrospun polymer nanofiber composites (HENC).
  • To explore the potential of HENC in drug delivery and tissue engineering.
  • To discuss future perspectives for advanced functional HENC materials.

Main Methods:

  • Review of electrospinning techniques and HENC preparation methods.
  • Analysis of HENC properties for drug release modulation.
  • Examination of HENC applications in biomedical fields.

Main Results:

  • HENC integrate hydrogel and nanofiber advantages for enhanced material properties.
  • These composites exhibit tunable drug release kinetics and biomimetic characteristics.
  • HENC show promise for various drug delivery applications.

Conclusions:

  • HENC represent a versatile platform for developing advanced functional materials.
  • Further research can optimize HENC for improved therapeutic efficacy and biomedical adaptability.
  • The combination of hydrogels and nanofibers holds significant potential for future innovations in regenerative medicine and drug delivery.