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Gelatin Methacrylate Coating on 3D-Printed Poly(esterurethane) Scaffolds Improves Cell Adhesion and Proliferation.
Nayla Jimena Lores1,2, Samanta Del Veliz3, Lautaro Rivera3
1Research Institute for Materials Science and Technology, INTEMA (CONICET-UNMdP), Av. Cristóbal Colón 10850, B7606WV, Mar del Plata, Argentina.
Chembiochem : a European Journal of Chemical Biology
|October 28, 2025
Summary
Surface modification of segmented poly(esterurethanes) (SPEU) scaffolds with gelatin methacrylate (GelMA) significantly improved cell adhesion and proliferation. These enhanced scaffolds show promise as biomaterials for tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Segmented poly(esterurethanes) (SPEU) are versatile polymers for elastomeric scaffolds in tissue engineering.
- SPEU's inherent hydrophobicity limits cell adhesion and biocompatibility.
- Surface modification is crucial to enhance cell-material interactions.
Purpose of the Study:
- To enhance the biocompatibility of 3D-printed SPEU scaffolds.
- To investigate the effect of gelatin methacrylate (GelMA) surface modification on cell interactions.
- To evaluate GelMA-SPEU scaffolds as potential extracellular matrices.
Main Methods:
- Fabrication of 3D-printed SPEU60 scaffolds (60% hard segment content).
- Surface modification via dip-coating with GelMA.
- Characterization using SEM, FTIR, and goniometry.
- In vitro evaluation of cell adhesion, proliferation, and viability using 3T3-L1 cells.
Main Results:
- GelMA coating significantly enhanced cell adhesion, proliferation, and viability on SPEU scaffolds.
- Surface modification successfully improved the bioactivity of the SPEU material.
- Characterization confirmed the successful modification and structural integrity of the scaffolds.
Conclusions:
- GelMA-coated SPEU60 scaffolds demonstrate improved cellular response.
- These modified scaffolds show potential as advanced biomaterials for tissue engineering.
- The GelMA-SPEU60 structures can serve as effective extracellular matrices.
