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Personalized Nutrition in Pediatric Chronic Diseases
Marlene Escobedo-Monge1,2,3, Robert H Lustig4, Sergey Suchkov5,6,7,8,9,10,11
1Department of Pediatrics, Faculty of Medicine, University of Valladolid, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain.
Metabolites
|October 28, 2025
Summary
Personalized nutrition (PN) uses multi-omics data to tailor diets for children with chronic conditions. Challenges remain in making these advanced insights practical and accessible for all.
Area of Science:
- Pediatric Nutrition Science
- Genomics and Metabolomics
- Chronic Disease Management
Background:
- Personalized nutrition (PN) offers a promising approach to optimize child health.
- Chronic pediatric conditions like obesity, type 2 diabetes, and celiac disease require tailored interventions.
- Multi-omics and trans-omics data hold potential for understanding individual health needs.
Purpose of the Study:
- To review the application of multi-OMICS and trans-OMICS in personalized nutrition for pediatric populations.
- To identify biomarkers and gene-environment interactions relevant to chronic pediatric conditions.
- To explore the translation of molecular insights into individualized dietary guidance.
Main Methods:
- Narrative review of existing scientific literature.
- Synthesis of evidence on multi-omics and trans-omics applications in pediatric nutrition.
- Analysis of gene-environment interactions and biomarker identification.
Main Results:
- Personalized nutrition strategies show potential for managing pediatric obesity, type 2 diabetes, and celiac disease.
- Biomarkers and gene-environment interactions are key to tailoring dietary recommendations.
- Translating complex molecular data into practical dietary guidance faces significant hurdles.
Conclusions:
- Personalized nutrition, informed by multi-omics, is a promising strategy for pediatric health optimization.
- Key challenges include cost-effectiveness, equity, and practical implementation in clinical settings.
- Integration into clinical practice requires policy development and standardized methodologies for accessibility.
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