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Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
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Value shift in response to aging: a longitudinal study based on healthy aging.

Yiran Shen1, Ruoyun Cao1, Xue Sang1

  • 1School of Public Health, Suzhou Medical college of Soochow University, Suzhou, China.

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|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Healthy aging relies on intrinsic capacity (IC) and functional ability (FA). Longitudinal study shows IC significantly impacts FA over time, with multimorbidity as a partial mediator, highlighting the need for proactive, person-centered health interventions.

Keywords:
Cross-lagged modelHealthy agingLongitudinal studyValue shift

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Area of Science:

  • Gerontology and Public Health
  • Longitudinal Health Studies
  • Aging Research

Background:

  • Healthy aging is crucial for managing age-related challenges.
  • Intrinsic capacity (IC) and functional ability (FA) are key components of healthy aging.
  • Longitudinal changes and interactions between IC and FA require further investigation.

Purpose of the Study:

  • To analyze the longitudinal structure, intensity, and mediation of changes in IC and FA.
  • To examine the dynamic relationship between IC and FA over time.
  • To identify mediating factors in the IC-FA relationship for healthy aging.

Main Methods:

  • Constructed a theoretical model of healthy aging.
  • Utilized the China Health and Retirement Longitudinal Study (CHARLS) database.
  • Employed factor analysis for IC, disability measures for FA, and cross-lagged panel models for longitudinal analysis.

Main Results:

  • IC is normally distributed, positively correlated with education and income.
  • Significant cross-lagged effects were found between IC and FA, with IC having a stronger influence on FA.
  • The effect of IC on FA intensifies over time; multimorbidity partially mediates this relationship.

Conclusions:

  • Diseases represent a stage in FA development, with IC being the foundational factor.
  • Current health policies should prioritize assessing and maintaining IC before disease onset.
  • A shift towards people-centered, rather than disease-centered, healthcare is essential for value transformation.