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Timing of Single-Tooth Implant Rehabilitation and Periapical Inflammation Severity: A Retrospective Study Using the
Pascal Grün1,2, Marius Meier1, S M Ragib Shahriar Islam3,4,5
1Center for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstraße 124, 3500 Krems an der Donau, Austria.
Diagnostics (Basel, Switzerland)
|October 29, 2025
Summary
Procedural timing for single-tooth implants did not correlate with periapical inflammation severity (DAIS). However, tooth location and patient age may influence treatment planning for dental implant restorations.
Area of Science:
- Dentistry
- Oral Surgery
- Implantology
Background:
- Periapical inflammation severity, assessed by the Dental Apical Inflammation Score (DAIS), is a critical factor in dental implant success.
- Understanding the relationship between procedural timing and periapical inflammation is essential for optimizing implant treatment protocols.
Purpose of the Study:
- To investigate the association between the timing of single-tooth implant-supported restorations and the severity of periapical inflammation (DAIS).
- To analyze procedural intervals (extraction to implant placement and restoration) in relation to DAIS.
- To identify clinical parameters influencing periapical inflammation in implant patients.
Main Methods:
- Retrospective study of 87 patients undergoing single-tooth implant restorations.
- Analysis of procedural intervals: extraction, socket preservation, implant placement, and prosthetic restoration.
- Statistical analysis including ANOVA, chi-square tests, and Pearson's correlation to assess relationships between timing, DAIS, tooth location, age, endodontic status, and sex.
Main Results:
- No significant differences in procedural timing were found across different DAIS severity groups.
- A significant association was observed between higher DAIS scores and specific tooth locations.
- Patient age showed a weak but significant positive correlation with DAIS scores.
Conclusions:
- Implant restoration timing does not appear to be significantly influenced by the severity of periapical inflammation alone.
- Tooth location and patient age are potential factors to consider in clinical decision-making for implant treatment planning.
- Current findings suggest that DAIS severity alone may not necessitate substantial modifications to standard implant timing protocols.

