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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jan 13, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

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Inherited Retinal Diseases with High Myopia: A Review.

Cyndy Liu1, Narin Sheri1, Matthew D Benson1

  • 1Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Genes
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

High myopia can be an early sign of inherited retinal dystrophies (IRDs), a group of genetic eye disorders. Recognizing this link aids in early molecular diagnosis and timely patient care.

Keywords:
axial myopiahigh myopiainherited retinal dystrophyretinal degeneration

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Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • Inherited retinal dystrophies (IRDs) are monogenic disorders affecting retinal function.
  • High myopia is a frequent clinical manifestation in various IRDs.
  • Identifying high myopia as a diagnostic clue can facilitate early detection of IRDs.

Purpose of the Study:

  • To review and summarize the associations between monogenic IRDs and high myopia.
  • To guide clinicians in establishing molecular diagnoses for patients with IRDs and high myopia.
  • To consolidate knowledge on genes implicated in IRDs with high myopia.

Main Methods:

  • Comprehensive literature review of PubMed, ScienceDirect, and JAMA Network.
  • Identification of studies linking monogenic IRDs with high myopia.
  • Categorization of associated genes based on their functions.

Main Results:

  • Genes associated with IRDs and high myopia fall into categories: collagen/structural integrity, phototransduction/visual cycle, ciliary trafficking, synaptic signaling, and opsin-related genes.
  • The association spans stationary and progressive retinal disorders, affecting both rod and cone functions.
  • Symptoms like nyctalopia and photophobia alongside high myopia increase suspicion for IRDs.

Conclusions:

  • High myopia is a significant clinical feature that warrants investigation for underlying IRDs.
  • Early diagnosis through molecular methods can improve patient outcomes via genetic counseling and clinical trial access.
  • Understanding gene clusters provides insights into the pathophysiology of IRDs with high myopia.