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Related Concept Videos

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

562
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
562
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
870
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

256
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
256
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

804
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
804
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

294
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
294
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

377
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
377

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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
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Non-Protein-Coding RNA and Acute Kidney Injury: New Developments from Pathogenesis to Potential Biomarker.

Grazia Maria Virzì1,2, Anna Clementi2,3, Monica Zanella1,2

  • 1Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy.

Genes
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

MicroRNAs show promise as early biomarkers for Acute Kidney Injury (AKI), detecting the condition sooner than traditional markers. Further research could lead to new diagnostic tools and treatments for AKI.

Keywords:
AKImicroRNAmicrovesciclesnon-protein-coding RNA

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nephrology

Background:

  • Acute Kidney Injury (AKI) is a critical condition with high mortality rates.
  • Early diagnosis of AKI is challenging with current biomarkers.
  • Small non-coding RNAs, particularly microRNAs (miRNAs), are emerging as potential diagnostic and therapeutic agents.

Purpose of the Study:

  • To review recent findings on the role of non-coding RNAs, specifically miRNAs, in AKI.
  • To highlight the potential of miRNAs as early diagnostic biomarkers for AKI.
  • To explore the therapeutic applications of miRNAs in AKI management.

Main Methods:

  • This is a narrative review, synthesizing existing research.
  • Focuses on studies investigating microRNAs in the context of Acute Kidney Injury.
  • Examines evidence for miRNA stability and diagnostic accuracy in biological fluids.

Main Results:

  • Specific miRNAs (e.g., miR-21, miR-30, miR-494, miR-29) can detect AKI earlier than serum creatinine.
  • miRNAs are stable in biofluids like plasma and urine, making them accessible biomarkers.
  • These miRNAs regulate gene expression and are implicated in AKI pathogenesis.

Conclusions:

  • MicroRNAs hold significant potential as sensitive biomarkers for early AKI detection.
  • miRNAs may offer novel therapeutic targets for AKI treatment.
  • Further clinical validation is required to translate these findings into patient care.