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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Deep Brain Stimulation for Parkinson's Disease-A Narrative Review
Rafał Wójcik1, Anna Dębska1, Karol Zaczkowski1
1Department of Neurosurgery and Oncology of Central Nervous System, Barlicki University Hospital, Medical University of Lodz, 90-153 Lodz, Poland.
Biomedicines
|October 29, 2025
Summary
Optimizing deep brain stimulation (DBS) for Parkinson's disease involves advanced imaging and targeting of the subthalamic nucleus (STN) and dentato-rubro-thalamic tract (DRTt) for improved motor function.
Area of Science:
- Neurosurgery
- Neurology
- Medical Imaging
Background:
- Deep brain stimulation (DBS) is a key treatment for Parkinson's disease (PD) motor symptoms.
- Current strategies primarily target the subthalamic nucleus (STN).
- Optimizing DBS requires advanced anatomical and functional approaches.
Purpose of the Study:
- To review strategies for enhancing DBS efficacy in Parkinson's disease.
- To explore novel targets like the dentato-rubro-thalamic tract (DRTt).
- To discuss advanced imaging and modeling for personalized treatment.
Main Methods:
- Review of clinical data and imaging techniques.
- High-resolution MRI and diffusion tensor imaging (DTI) tractography for target visualization.
- Electric field modeling for stimulation efficacy prediction.
Main Results:
- Co-stimulation of STN and DRTt shows superior motor outcomes in PD patients.
- Improved bradykinesia, rigidity, and tremor control with combined targeting.
- High-resolution imaging enables precise targeting and patient-specific planning.
Conclusions:
- Advanced imaging and targeting, including DRTt, optimize DBS for Parkinson's disease.
- Patient-specific approaches and network-based stimulation are crucial.
- Future directions include adaptive stimulation and multimodal biomarkers.
